Brief description of the drug Emetrol (domperidone)


An irregular or improper diet can lead to stomach discomfort Emetrol– helps digestion by acting on the stomach muscles and helping to alleviate unpleasant symptoms.


Brief description of the drug Emetrol (domperidone)
  • A complex of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux, esophagitis: A feeling of overflow in epigastrium, a feeling of bloating, pain in upper abdomen; belching, flatulence; nausea, vomiting; heartburn, belching.
  • Nausea and vomiting of functional, organic, infectious origin, as well as caused by radiotherapy, drug therapy or dietary disorders. A specific indication is nausea and vomiting caused by dopamine agonists when used in Parkinson’s disease (such as levodopa and bromocriptine).


Brief description of the drug Emetrol (domperidone)

Hypersensitivity to domperidone or any of the drug components; prolactin-secreting pituitary tumor (prolactinoma); concomitant use of oral forms of ketoconazole, erythromycin or other potent inhibitors of CYP3A4 isoenzyme, which cause prolongation of QTc interval, such as clarithromycin, itraconazole, fluconazole, posaconazole, ritonavir, saquinavir, amiodarone, telithromycin, telaprevir and voriconazole; Gastrointestinal bleeding, mechanical obstruction, or perforation (i.e. i.e. when stimulation of gastric motility may be dangerous); moderate to severe hepatic dysfunction; phenylketonuria; body weight less than 35 kg.


Symptoms. Cases of overdose have been observed mainly in infants and older children. Symptoms of overdose may include hyperexcitability, altered consciousness, seizures, disorientation, somnolence, and extrapyramidal reactions.
Treatment. There is no specific antidote for domperidone. In case of overdose, gastric lavage within one hour of taking the drug and use of activated charcoal is recommended. It is recommended to closely monitor the patient’s condition and provide supportive therapy. Anticholinergic agents and drugs used to treat parkinsonism may be effective in stopping extrapyramidal reactions that have occurred.

Considering the side effects on the nervous system, patients need to be careful when driving motor vehicles or operating other mechanisms. The data on post-marketing use of domperidone in pregnant women are limited. Therefore, during pregnancy should be administered only when, in the opinion of the physician, the expected positive effect for the mother exceeds the potential risk for the fetus. The amount of the drug that may enter the body of the infant with the breast milk is extremely low. The maximum relative dose to infants (%) is estimated to be about 0.1% of the maternal dose, adjusted for body weight. It is not known if it is harmful to the baby, so mothers taking emetrol should refrain from breastfeeding. Caution should be exercised if there are risk factors for QTc interval prolongation in breastfed infants. After exposure as a result of penetration of emetrol into breast milk, side effects, particularly cardiac effects, cannot be ruled out.